Do I have to take oral PrEP every day?

No, not necessarily. There are two dosing schedules for oral PrEP, and the choice depends on your needs.

Both methods are highly effective when followed correctly. Your pharmacist will help you choose the best option for you.

Option 1: Continuous PrEP (daily use)

This is the most common schedule and the only one recommended for all types of sexual intercourse (anal and vaginal).

• How it works: You take one pill every day, at around the same time.
• Ideal for: People who have frequent or unpredictable sex, or for anyone who has vaginal sex. It is also the only option for people living with chronic hepatitis B.
• Advantage: It provides constant, maximum protection without needing to plan ahead and predict your sexual activity.

Option 2: On-Demand PrEP (2-1-1 schedule)

This flexible method is a validated option for anal sex only (active or passive).

• How it works (2-1-1 protocol):
  1. Take 2 pills at the same time, between 2 and 24 hours before sexual intercourse.
  2. Take 1 pill, 24 hours after the first dose.
  3. Take 1 final pill, another 24 hours later (48 hours after the first dose).
• Ideal for: People who can anticipate their sexual activity or who have sex more occasionally.
• Advantage: It reduces the total number of pills you need to take.

Important: Never switch your dosing schedule without talking to a healthcare professional. The on-demand schedule must be followed exactly to be effective.