How long does it take for PrEP to become effective after starting treatment?

Protection is not always instantaneous; the time it takes to become effective depends on the type of PrEP you are using.

Each method has its own protocol for achieving maximum protection.

Daily Oral PrEP

This is the most studied method. The delay varies depending on the type of sexual intercourse:

• For anal sex: Protection is optimal after 7 days of continuous daily use.
• For vaginal sex: Protection is optimal after 21 days of continuous daily use.

On-Demand Oral PrEP (2-1-1)

This method provides very rapid protection for anal sex only.

• Protection: Effective as soon as 2 hours after the initial double dose (2 pills), as long as the full protocol (2-1-1) is followed correctly.

Injectable PrEP

This method provides continuous protection for all types of sexual intercourse.

• Protection: Protection is considered optimal 7 days after the first injection.

It is essential to respect these timelines and to use additional protection (like a condom) until maximum protection is achieved.