What is Doxy-PEP (or Doxy-PPE)?

Doxy-PEP is a prevention strategy that uses an antibiotic, doxycycline, after a risky sexual encounter to reduce the chances of contracting certain bacterial STIs.

It is crucial to understand that Doxy-PEP does not protect against HIV or other viral STIs like herpes or HPV.

How does it work?

The principle is simple: it involves taking a single dose of 200 mg of doxycycline as soon as possible after condomless sex, ideally within 24 hours and no later than 72 hours. You can think of it as the "morning-after pill" for bacterial STIs.

How effective is it?

Major scientific studies have shown very encouraging effectiveness. Among the most studied populations (men who have sex with men and transgender women), Doxy-PEP reduces the risk of contracting:

• Syphilis: by about 70% to 90%
• Chlamydia: by about 70% to 80%
• Gonorrhea: a more modest reduction (about 0% to 50%), as more and more strains of gonorrhea are resistant to doxycycline.

Points to consider for an informed choice

• The use of antibiotics: Public health authorities closely monitor the use of antibiotics. That's why Doxy-PEP is offered on a targeted basis, after a discussion about the clear benefits for you versus this collective issue.
• An approach based on current data: For now, research has shown very clear benefits for certain populations (MSM and transgender women). Our recommendation is always based on the most solid scientific data.

Who is Doxy-PEP for right now?

This is not a general recommendation for the public. It is an option that is discussed on a case-by-case basis, primarily for people who are already on PrEP for HIV (or who are living with HIV with an undetectable viral load) and are at high risk of contracting an STI.

The decision to start Doxy-PEP is always made in discussion with your doctor or pharmacist. Make an appointment with our pharmacists to discuss it.

(information up to date in june 2025)